April 8, 2023 | Register
May 13, 2023 | Register
< fertility services

Natural & Mini Stim IVF

We offer lower cost alternatives to Conventional IVF: Natural IVF and Mini Stim IVF. Instead of aggressively stimulating the ovaries with high dose medication and then doing an egg retrieval, we can use one of these methods to achieve similar outcomes at a lower cost.

At a Glance

  • Less stressful because no or low doses of medicine are used
  • Monitoring is minimal
  • Less costly that Conventional IVF
  • Egg retrievals require no anesthesia for most patients
  • Embryo biopsy for genetic analysis cost is reduced
  • ICSI is also included in male factor situations

Lower Cost, Less Medication & Less Stress


Natural IVF got its start because women didn’t like all of the injections. Doctors in Japan developed Natural IVF to find ways to help these women conceive without all of the medication associated with Conventional IVF. Since then, Natural IVF has morphed into a very effective way to have excellent outcomes without pushing the ovaries to their max.

Through the years, it has been discovered that “more is not always better.” In Conventional IVF, the embryos which develop generally come from the best of the eggs and the other eggs have lower potential. In the Mini Stim IVF approach, lower numbers of follicles are developed and fewer, but sometimes higher quality eggs are retrieved.

Natural IVF uses no injectable medication. Mini Stim IVF is a hybrid of Natural where we use very low doses of medication. The Natural IVF and Mini Stim IVF approaches can produce the same number of pregnancies as a single cycle of Conventional IVF. However, since very low drug doses are used, it is more cost effective for the patient. In Conventional IVF, about a third of the patient’s cost is allocated to the use of the drugs.

How Natural IVF Works

Instead of stimulating the ovaries vigorously once and doing an egg retrieval, the same outcome can be achieved, at lower cost, by doing up to three cycles of Natural IVF. Egg retrievals are done without anesthesia using a tiny needle. It is done very quickly, and patients tolerate this very well. Anesthesia is available for those who request it at extra cost.

Once the eggs are retrieved, Conventional IVF laboratory procedures are followed. The eggs and sperm are placed together in the dish or intracytoplasmic sperm injection (ICSI) is used in cases of male factor. Fertilization is followed by embryo development. Five days later, if an embryo develops to the 80 to 100-cell stage called a blastocyst, it can be biopsied for genetic analysis, then frozen.

Once one or two chromosomally normal embryos are obtained, an embryo transfer can be performed with estrogen and progesterone medication. The frozen embryo transfer (FET) is performed the same way, no matter what type of IVF was done.

How Mini Stim IVF Works

Mini Stim IVF is a hybrid of Natural IVF. Low doses of oral and injectable drugs are used, and monitoring is minimal. In this approach a modest number of follicles develop. The same procedure as Natural IVF is followed once the follicles develop.

Natural & Mini Stim IVF Candidates

No one is excluded from this program because of age, AMH or past history. Patients who have poor prognosis are also offered the egg donation option. If this is not acceptable, Mini Stim IVF is more cost effective than Conventional IVF for poor prognosis patients because the high doses of expensive injectable gonadotropin often used are ineffective in Conventional IVF. Below are women who are good candidates for Natural IVF or Mini Stim IVF.


  • who have been told the only way they will conceive is with an egg donor
  • with diminished ovarian reserve (DOR)
  • who do not want lots of surplus embryos after conceiving
  • who do not tolerate the injection medication well
  • looking for a low-cost option
  • with PCOS
  • with no fallopian tubes
  • who want a more natural approach to conceiving
  • who want to do preimplantation genetic screening (PGT)

Older Women

Physicians often advise older patients in their 40’s who fail IVF to stop trying to use their own eggs and move to egg donor since that option offers 60% to 80% success. However, not everyone is ready to make that leap; some women want to keep trying with their own eggs. While egg donor is a wonderful solution for many people, for those who find that option unacceptable, persistence is the key word.

For older patients with diminished ovarian reserve (DOR), more gonadotropins does not result in more eggs retrieved. These patients are generally wasting their money on medication in Conventional IVF. With Natural and Mini Stim IVF, most of our patients choose a 3-cycle package. They have an egg retrieval with no anesthesia three months in a row. With all of the embryos biopsied and frozen, they can have a transfer with a normal embryo the next month. Once a normal embryo is created, even in a 44-year-old, the chances for implantation and a baby from this embryo are nearly as good as they are for a 30-year-old.

All of this is very low stress because the patient’s life is not overtaken by all of the daily injections and monitoring.

Low Ovarian Reserve

Younger women who have diminished ovarian reserve can be considered to have premature ovarian aging. Similar to 44-year-old patients, sometimes only 10% of eggs and their resulting embryos are chromosomally normal or euploid. Patients with low ovarian reserve have an elevated FSH level. Conventional IVF often tries to stimulate follicles by using a high dose of gonadotropins (FSH). Since these patients already have an elevated FSH, the stimulation does not produce more eggs. Also, the quality of the eggs can be negatively affected by high dose stimulation. So, Mini Stim IVF can work just like it can in an older woman. It can be just as effective as Conventional IVF, just easier and less expensive.

Mini Stim IVF vs Conventional IVF

The three elements which are so taxing in Conventional IVF are:

  1. Time – lots of tests, ultrasounds, doctor’s visits, and waiting room time
  2. Money – the procedures and the drugs add up to considerable amounts
  3. Stress – intense treatment cycles occupy one’s life

The first two add to the emotional stress, which is unresolved when patients do not conceive. Mini Stim IVF requires less of each of these elements and gives hope to patients who need to persist. It is often impractical to keep doing Conventional IVF due to the cost.

If you have tried IVF and you are thinking about trying Mini Stim IVF, on the surface it may seem counterintuitive. Patients have always been told that the goal is to get as many eggs as possible. Natural IVF and Mini Stim IVF is a way to keep trying with less money and stress compared to Conventional IVF. Typically, one mid cycle ultrasound can be done, and the date of trigger can be set. You walk into the egg retrieval fully alert, endure a couple of minutes of being uncomfortable, and you are free to go about your day. No post anesthesia recovery time. No one has to take you home. You could even go back to work.

Genetic Analysis

As a part of Natural IVF and Mini Stim IVF, a unique feature is the recommended use of preimplantation genetic testing (PGT). This analysis of the chromosomes in each embryo means that we only transfer normal embryos, improving the chances of a successful pregnancy.

We offer a discount on the biopsy in our 3-cycle packages.

Hear more directly from Dr. Dourron

Who is a Good Candidate for Natural and Mini Stim IVF?

I Felt Like I Was Visiting Friends
I Felt Like I Was Visiting FriendsREAD MORE
Read More
They were genuinely compassionate about our situation and listened to our concerns and opinions. His laid back personality put us at ease and was a stark contrast to the other doctors we had seen who were always rushed, condescending, and egotistical.
After Several Unsuccessful IUI Attempts at Another Specialist
After Several Unsuccessful IUI Attempts at Another SpecialistREAD MORE
Read More
Wow – what a difference they made in our infertility journey. They truly made us feel like family.
I Felt Special – Not Like Just Another Number
I Felt Special – Not Like Just Another NumberREAD MORE
Read More
Dr. Massey and his clinic gave me hope when I didn’t feel like there was any.
Patient, Compassionate, Sincere
Patient, Compassionate, SincereREAD MORE
Read More
I began this IVF process at two other clinics but never felt comfortable … This practice was much more affordable and flexible right from the start! There was no unnecessary testing and, more importantly, no long waits.
We Could Only Do IVF If It Was Affordable
We Could Only Do IVF If It Was AffordableREAD MORE
Read More
We were so blessed that our first IVF round worked! We had our little girl in April 2013. She is an amazing gift and I thank Dr. Massey and his staff for giving her to us.
Thank God, After All These Years, We Finally Found our Doctor!
Thank God, After All These Years, We Finally Found our Doctor!READ MORE
Read More
Dr. Massey was always so confident about going against all the odds we’ve had in our way to build our family. I will never forget his words: “Ok, ain’t gonna be easy BUT we are gonna make it happen.” Those words were music to our ears. Infertility sucks (we all know that!) and certainly there’s nothing else you want to hear than there’s hope and there’s always a way to make it happen.
I Dealt with Years of PCOS & Endometriosis
I Dealt with Years of PCOS & EndometriosisREAD MORE
Read More
With the sincerest gratitude, Dr. Massey and team...I THANK YOU!
The Other Clinic Told Us to Adopt
The Other Clinic Told Us to AdoptREAD MORE
Read More
A family friend encouraged us to take one last look at IVF. We knew we did not want to go back to the same doctor, so we began looking for someone new. My wife was then 37 and I was 32. We were very fortunate to find Dr. Massey's office where they offered the IVF process for almost half of what the previous doctor charged.
We Got Married Later in Life
We Got Married Later in LifeREAD MORE
Read More
I got married in my late 30s as many women do these days, never imagining that I would have fertility issues.
They Let Me Do Monitoring in My Home Town
They Let Me Do Monitoring in My Home TownREAD MORE
Read More
We were so excited and knew that this time it was going to work and it did! We now have a 5-month-old boy that we feel is our little miracle.
Personalized Care AND Low Cost!
Personalized Care AND Low Cost!READ MORE
Read More
Our son recently turned 10 months old and is happy and healthy in every way possible. We have begun the planning for our next child and look forward to working with them again.
Nine Years of Patience Brings Eduardo, Jr.
Nine Years of Patience Brings Eduardo, Jr.READ MORE
Read More
Thank you to all who have made my husband and I so happy and for taking the time to explain each step of our journey.
We Were Dealing with Male Factor Infertility
We Were Dealing with Male Factor InfertilityREAD MORE
Read More
We are so thankful to have found Dr. Massey online when we searched “low cost IVF centers” on Google. We have beautiful twins because of it! Our fertility journey began in 2005 when we started trying to conceive but knew we had some potential obstacles to deal with even though I was only 23 years old.
An Individualized Treatment Plan Was Key
An Individualized Treatment Plan Was KeyREAD MORE
Read More
Our gratitude is immeasurable. Thank you so, so much!
Single Mother by Choice
Single Mother by ChoiceREAD MORE
Read More
"On the second IVF cycle I got pregnant and now I have a beautiful little boy!"